Minireview: PRKAR1A: Normal and Abnormal Functions
نویسندگان
چکیده
منابع مشابه
Minireview: GNAS: normal and abnormal functions.
GNAS is a complex imprinted gene that uses multiple promoters to generate several gene products, including the G protein alpha-subunit (G(s)alpha) that couples seven-transmembrane receptors to the cAMP-generating enzyme adenylyl cyclase. Somatic activating G(s)alpha mutations, which alter key residues required for the GTPase turn-off reaction, are present in various endocrine tumors and fibrous...
متن کاملMinireview: Cyclin D1: normal and abnormal functions.
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate canc...
متن کاملThe Exocrine Pancreas: Normal and Abnormal Functions
The selection of topics, caliber of participants and content of the proceedings of this symposium reflect the high standards of the Ciba Foundation for scientific excellence. The broad range of topics covered by international authorities, together with the discussion, has been extremely well edited and the material is compiled in a logical sequence. The section on ultrastructure and histochemis...
متن کاملNormal Abnormal Normal Abnormal
reference electrode (3). The ionized calcium concentration of sequential retentates prepared by ultrafiltration of a human control serum increased with increasing protein concentration in a way consistent with Donnan theory (4, 5) when the analyzers’ standard reference-electrode liquid junctionswere used; however, the ionized calcium in the same retentates declined slightly with increasing prot...
متن کاملT-type Ca2+ channels in normal and abnormal brain functions.
Low-voltage-activated T-type Ca(2+) channels are widely expressed in various types of neurons. Once deinactivated by hyperpolarization, T-type channels are ready to be activated by a small depolarization near the resting membrane potential and, therefore, are optimal for regulating the excitability and electroresponsiveness of neurons under physiological conditions near resting states. Ca(2+) i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2004
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2004-0900